Continuous flow synthesis of therapeutic pharmaceutical compounds has been demonstrated with the Vortex Fluidic Device, and shown to be particularly effective when performed via two serially-linked VFDs. In one example demonstration optimised monophasic flow conditions were shown to be effective in executing the total synthesis of the local anesthetic lidocaine in less than 80 seconds and at 85% yield.
For additional information please see the following peer-reviewed scientific paper that demonstrates this optimised synthesis process:
· Rapid Vortex Fluidics: Continuous Flow Synthesis of Amides and Local Anesthetic Lidocaine
The diagram below summarises the comparison of conventional lidocaine synthesis via separate steps and continuous flow with the VFD.